Overview
Zerodol SP is a combination tablet made by Ipca Laboratories Ltd. Each tablet contains aceclofenac 100mg, acetaminophen 325mg (called paracetamol outside the US) and serratiopeptidase 15mg. It is used for pain relief.
- Aceclofenac 100mg — anti-inflammatory painkiller (NSAID)
- Acetaminophen 325mg — pain reliever and fever reducer
- Serratiopeptidase 15mg — protein-digesting enzyme
- Take only as your doctor prescribes
Uses
Zerodol SP is used for pain relief. According to each ingredient’s official product information:
- Aceclofenac relieves pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
- Acetaminophen temporarily relieves minor aches and pains (such as headache, muscular aches, backache, minor arthritis pain and toothache) and reduces fever.
- Serratiopeptidase is an enzyme that helps clear fluid at the site of inflammation and reduce swelling.
Also available: Zerodol 100mg and Zerodol CR 200mg (aceclofenac only). See more pain relievers.
How it works
- Aceclofenac blocks the cyclo-oxygenase (COX) enzyme, which reduces the body’s production of prostaglandins — chemicals involved in pain, swelling and inflammation.
- Acetaminophen relieves pain and lowers fever.
- Serratiopeptidase breaks down substances involved in inflammation (such as bradykinin), which helps clear fluid from inflamed tissue, reduce swelling and improve local blood flow.
Dosage
Take Zerodol SP exactly as your doctor prescribes. Important dose limits from each ingredient’s official label:
- Aceclofenac: the usual adult dose is 200mg a day (each Zerodol SP tablet has 100mg, so 200mg is the amount in 2 tablets). Use the lowest effective dose for the shortest time needed.
- Acetaminophen: severe liver damage may occur if an adult takes more than 4,000mg in 24 hours from all medicines combined.
- Aceclofenac is preferably taken with or after food.
- Liver problems: aceclofenac’s dose should be reduced; ask your doctor before using acetaminophen if you have liver disease.
- Children: aceclofenac is not recommended for children.
Safety warning
- Liver warning (acetaminophen): severe liver damage may occur if you take more than 4,000mg of acetaminophen in 24 hours, take it with other medicines that contain acetaminophen (including Tylenol and many cold and flu products), or have 3 or more alcoholic drinks every day while using it.
- Do not take Zerodol SP if you: are allergic to any of its ingredients; have an active or repeated stomach ulcer or bleeding; have had stomach bleeding or a perforation from an NSAID; have had asthma, runny nose, swelling or hives after aspirin, ibuprofen or other NSAIDs; have liver or kidney failure; have heart failure, heart disease, poor circulation in the legs, or stroke/mini-stroke; have active bleeding or a bleeding disorder; or are in the last 3 months of pregnancy.
- Stomach bleeding: NSAIDs can cause bleeding, ulcers or perforation at any time, with or without warning, and this can be fatal. Stop and get help if you have black stools or vomit blood.
- Heart and blood vessels: aceclofenac is broken down to diclofenac, which is linked to a small increase in the risk of heart attack or stroke. It can also cause fluid retention and swelling.
- Skin: acetaminophen and NSAIDs can cause rare but severe skin reactions. Stop use and get medical help right away if you get skin reddening, blisters or a rash.
- Bleeding (serratiopeptidase): serratiopeptidase might reduce blood clotting and increase bruising and bleeding, especially with blood thinners or antiplatelet medicines.
- Asthma: NSAIDs can trigger breathing problems in people with asthma.
- May cause dizziness, drowsiness or tiredness — if affected, do not drive or use machines.
- Overdose: get medical help or call Poison Control (1-800-222-1222) right away, even if you feel well.
Side effects
Common side effects of aceclofenac (up to 1 in 10 people) include:
- Indigestion (dyspepsia)
- Stomach pain
- Nausea
- Diarrhea
- Dizziness
- Raised liver enzymes
Less common or rare effects include vomiting, gas, constipation, mouth ulcers, itching, rash, swelling (edema), high blood pressure, stomach ulcer or bleeding, black stools, liver problems or jaundice, kidney problems, low blood counts and severe skin reactions. Get medical help straight away for any serious symptom.
Interactions
- Other medicines containing acetaminophen (prescription or over-the-counter): do not take together.
- Other NSAIDs, including aspirin, ibuprofen, naproxen and COX-2 inhibitors: avoid — more stomach side effects and bleeding.
- Blood thinners such as warfarin and antiplatelet medicines (such as clopidogrel): higher risk of bleeding from all three ingredients; ask your doctor first.
- Corticosteroids and SSRI antidepressants: higher risk of stomach ulcers or bleeding.
- Blood pressure medicines (ACE inhibitors, ARBs) and diuretics: their effect may be reduced and the risk of kidney problems goes up.
- Lithium, digoxin and methotrexate: their levels or toxicity may increase.
- Cyclosporine and tacrolimus: higher risk of kidney damage.
- Quinolone antibiotics: possible higher risk of seizures.
- Mifepristone: NSAIDs should not be used for 8–12 days after it.
Tell your doctor about all the medicines, vitamins and herbal supplements you take.
Pregnancy & breastfeeding
Do not use aceclofenac in the last 3 months (third trimester) of pregnancy. In the first 6 months it should only be used if clearly needed, at the lowest dose for the shortest time. Aceclofenac should be avoided while breastfeeding unless the benefit clearly outweighs the risk, and it may reduce female fertility. If you are pregnant or breastfeeding, ask a health professional before use.
Storage
Store below 30°C (86°F), protected from light and moisture. Keep out of the reach of children.
Pack sizes & prices
| Pack | Price per tablet | Pack price |
|---|---|---|
| 60 Tablets | $1.61 | $96.60 |
| 90 Tablets | $1.51 | $135.90 |
| 120 Tablets | $1.45 | $174.00 |
| 180 Tablets | $1.36 | $244.80 |
See our shipping policy for delivery times and costs, and how ordering works. Browse all medications.
FAQs
What is in Zerodol SP?
Each tablet contains aceclofenac 100mg, acetaminophen (paracetamol) 325mg and serratiopeptidase 15mg. It is made by Ipca Laboratories.
Is paracetamol the same as acetaminophen?
Yes. Paracetamol is the name used outside the US; in the US the same medicine is called acetaminophen (the ingredient in Tylenol).
How many Zerodol SP tablets can I take a day?
Take it exactly as your doctor prescribes. Each tablet has 100mg of aceclofenac, and the official aceclofenac label gives a usual adult dose of 200mg a day (the amount in 2 tablets). Do not take more than your doctor tells you.
Can I take Zerodol SP with Tylenol or other cold medicines?
No, not without asking your doctor. Do not take it with any other medicine that contains acetaminophen (paracetamol), including many cold and flu products. Too much acetaminophen can cause severe liver damage.
Can I take it with ibuprofen or aspirin?
No. Aceclofenac is an NSAID, and taking it with other NSAIDs such as ibuprofen, naproxen or aspirin raises the risk of stomach bleeding and other side effects.
Can I take Zerodol SP during pregnancy?
Aceclofenac must not be used in the last 3 months of pregnancy, and earlier only if clearly needed. Ask your doctor before using it if you are pregnant or breastfeeding.
Sources: aceclofenac — UK Summary of Product Characteristics for Preservex 100 mg tablets on the electronic medicines compendium (emc); acetaminophen — US Drug Facts label for acetaminophen 325 mg tablets (DailyMed); serratiopeptidase — Summary of Product Characteristics for an aceclofenac, paracetamol and serratiopeptidase tablet (Kenya Pharmacy and Poisons Board). This page is for information only and does not replace advice from your doctor or pharmacist.
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