Overview
Acamprol 333mg is a tablet that contains acamprosate 333mg. It is made by Sun Pharmaceutical Industries Ltd and is a generic version of Campral. Acamprosate is used to help adults with alcohol dependence keep from drinking (stay abstinent) after they have stopped drinking alcohol.
- Acamprosate 333mg per tablet
- Generic version of Campral
- Helps maintain abstinence from alcohol
- Usually 2 tablets, three times a day
Uses
According to the official label, acamprosate is used for the maintenance of abstinence from alcohol in people with alcohol dependence who are not drinking when treatment starts.
- It should be part of a full treatment program that includes counselling and support.
- It has not been shown to work in people who have not gone through detox and stopped drinking before starting it.
- How well it works in people who also misuse other substances has not been fully studied.
See more anti-alcoholism medicines.
How it works
The exact way acamprosate helps people stay alcohol-free is not completely understood. Long-term drinking is thought to upset the normal balance between nerve signals in the brain that excite and those that calm. Animal studies suggest acamprosate acts on the brain’s glutamate and GABA systems and may help restore this balance.
Dosage
Take Acamprol exactly as your doctor prescribes. The doses on the official label are:
- Usual dose: two 333mg tablets (666mg) three times a day. A lower dose may work for some people.
- Moderate kidney problems (creatinine clearance 30–50 mL/min): one 333mg tablet three times a day.
- Severe kidney problems (creatinine clearance 30 mL/min or less): do not take acamprosate.
- It can be taken with or without food; taking it with meals is suggested for people who eat three meals a day.
- Start as soon as possible after alcohol withdrawal, once you have stopped drinking, and keep taking it even if you drink again — tell your doctor about any drinking.
Safety warning
- Depression and suicidal thoughts: in clinical trials, suicidal thoughts, suicide attempts and suicides were uncommon but happened more often with acamprosate than with placebo. Patients, families and caregivers should watch for signs of depression or suicidal thinking and report them to the doctor right away.
- Kidney problems: the dose must be lowered in moderate kidney problems, and acamprosate must not be used in severe kidney problems. Acute kidney failure has been reported rarely.
- Alcohol withdrawal: acamprosate does not stop or reduce withdrawal symptoms.
- Allergy: do not take it if you have had an allergic reaction to acamprosate calcium or any of its ingredients.
Side effects
Common side effects in clinical trials (in 3% of patients or more, and more often than with placebo) were:
- Diarrhea
- Nausea
- Gas (flatulence)
- Loss of appetite
- Weakness
- Pain
- Accidental injury
- Anxiety
- Depression
- Dizziness
- Dry mouth
- Trouble sleeping (insomnia)
- Tingling or numbness
- Itching
- Sweating
Diarrhea was the only side effect that made more than 1% of patients stop treatment.
Interactions
- Acamprosate does not change how the body handles alcohol, and alcohol does not change how the body handles acamprosate.
- Diazepam and disulfiram do not affect acamprosate levels.
- No clinically important interactions were seen with naltrexone.
Tell your doctor about all the medicines, vitamins and herbal supplements you take.
Pregnancy & breastfeeding
Acamprosate caused birth defects in animal studies, so it should be used during pregnancy only if the possible benefit is worth the possible risk to the baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether acamprosate passes into human breast milk, so tell your doctor if you are breastfeeding.
Storage
Store at room temperature, 20°C to 25°C (68°F to 77°F); short periods between 15°C and 30°C (59°F to 86°F) are allowed. Keep out of the reach of children.
Pack sizes & prices
| Pack | Price per tablet | Pack price |
|---|---|---|
| 90 Tablets | $1.07 | $96.30 |
| 120 Tablets | $0.98 | $117.60 |
| 180 Tablets | $0.95 | $171.00 |
| 360 Tablets | $0.88 | $316.80 |
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FAQs
Is Acamprol 333mg the same as Campral?
Both contain acamprosate as the active ingredient. Acamprol is made by Sun Pharmaceutical Industries; Campral is the original brand name.
How many tablets do I take a day?
The usual dose is two 333mg tablets three times a day (666mg each time). People with moderate kidney problems take one tablet three times a day. Always follow your doctor’s dose.
Does it help with alcohol withdrawal symptoms?
No. Acamprosate does not stop or reduce withdrawal symptoms. It is started after withdrawal, once you have stopped drinking, to help you stay alcohol-free.
What if I drink again while taking it?
Keep taking acamprosate as directed even if you drink again, and tell your doctor about it.
Can I take it with or without food?
Yes, it can be taken with or without food. Taking it with meals was used in clinical trials and is suggested for people who eat three meals a day.
Who should not take acamprosate?
People with severe kidney problems, and people who are allergic to acamprosate calcium or any of its ingredients.
Source: FDA-approved prescribing information for acamprosate calcium delayed-release tablets 333 mg (generic Campral), Glenmark Pharmaceuticals Inc., USA, on DailyMed (May 2025). This page is for information only and does not replace advice from your doctor or pharmacist.
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